The differential effects of post-session administration of amineptine and imipramine on memory processes in mice
by
de Angelis L
Istituto di Farmacologia,
Facolta di Medicina e Chirurgia,
Universita di Trieste, Italy.
Methods Find Exp Clin Pharmacol 1990 Jan-Feb; 12(1):23-7


ABSTRACT

The effects of post-trial administration of amineptine, a dopaminergic antidepressant drug, were compared with those of memory-facilitating (strychnine, piracetam) or impairing drugs (phenobarbital, imipramine) on an experimental model of memory. Mice were given two sessions in open-field test and the decrease in activity at the second session (habituation) served as an index of retention. The good retention observed with a 1-day inter-session interval was impaired by post-session administration of phenobarbital (10 mg/kg i.p.) or imipramine (5.0 mg/kg i.p.). The poor retention observed with a 5-day inter-session interval was enhanced by post-session administration of strychnine (0.20 mg/kg i.p.), piracetam (1000 mg/kg i.p.) and amineptine (10 mg/kg i.p.). These findings show that different profiles of cognitive and psychomotor effects were produced by imipramine and amineptine. Amineptine, lacking sedative and anticholinergic properties which are characteristic of imipramine, interferes positively with learning and memory, in a manner similar to piracetam and strychnine.


Efficacy
Metabolism
Pharmacology
Amineptne: Italy
Amineptine excess
Amineptine and sex
Mesolimbic dopamine
Amineptine in Portugal
Amineptine v maprotiline
Amineptine v trimipramine
Amineptine v clomipramine
Amineptine and the elderly
Amineptine overconsumption
Amineptine and smarter dogs
Amineptine versus imipramine



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