Amineptine induced liver injury. Report of
two cases and brief review of the literature
by
Lazaros GA, Stavrinos C, Papatheodoridis GV,
Delladetsima JK, Toliopoulos A, Tassopoulos NC
First Department of Medicine,
Western Attica General Hospital,
Athens, Greece.
Hepatogastroenterology 1996 Jul-Aug; 43(10):1015-9

ABSTRACT

Two cases of amineptine induced liver injury in patients treated with the drug for 18 and 15 days respectively, are reported. Hepatic reaction lasted 60 days in the first case and 120 days in the second one, with the latter considered unusually prolonged. The patients history, the course of the reaction and the histologic findings were compatible with the diagnosis of drug induced liver disease in both cases. Furthermore, every other possible origin of hepatobiliary injury such as disorders of bile ducts, ongoing viral hepatitis and autoimmune hepatitis were excluded. The mechanism of amineptine induced liver injury and the influence of a possible genetic predisposition to amineptine hepatotoxicity are also discussed.

Efficacy
Pharmacology
Amineptine excess
Amineptine in Italy
Amineptine and sex
Mesolimbic dopamine
Amineptine and smart mice
Amineptine and smarter dogs
Amineptine and unipolar depression


Refs
HOME
HedWeb
BLTC Research
Paradise-Engineering
Utopian Pharmacology
The Hedonistic Imperative
When Is It Best to Take Crack Cocaine?

The Good Drug Guide
The Responsible Parent's Guide
To Healthy Mood Boosters For All The Family